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    Europe’s Favorite Vegan Chocolate Brand Vego Is Now In the US. Here’s Where to Buy It.

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    The Low Carb Diabetic: Octobers Birth Month Flowers

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    Fitness Innovator Adam Frater Redefines the Industry with “Project Shred”

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    Cube Club secures $1.1 million in seed fund to launch fitness social network Dopamine

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    Urvashi Rautela Serves Major Fitness Goals As She Enjoys A Quick Workout Session, Watch Video

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    The Political Power of the Food Industry

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    Top 3 Benefits of Infrared Sauna Blankets for Health and Recovery

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    Walking and Mediterranean diet may be the ticket to reducing dementia risk

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    Easy Applesauce Cake – The Big Man’s World ®

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    Simple Vegan Apple Tart Tatin

    Simple Vegan Apple Tart Tatin

    Europe’s Favorite Vegan Chocolate Brand Vego Is Now In the US. Here’s Where to Buy It.

    Europe’s Favorite Vegan Chocolate Brand Vego Is Now In the US. Here’s Where to Buy It.

    The Low Carb Diabetic: Octobers Birth Month Flowers

    The Low Carb Diabetic: Octobers Birth Month Flowers

    Bollywood Goes Vegan: 9 Actors Who Have Given Up Animal Products for Good

    Bollywood Goes Vegan: 9 Actors Who Have Given Up Animal Products for Good

    Red Lentil Butternut Squash Soup

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    Happy birthday, Rishabh Pant! Revealing the cricketer’s fitness secrets

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    Fitness Innovator Adam Frater Redefines the Industry with “Project Shred”

    Fitness Innovator Adam Frater Redefines the Industry with “Project Shred”

    Cube Club secures $1.1 million in seed fund to launch fitness social network Dopamine

    Cube Club secures $1.1 million in seed fund to launch fitness social network Dopamine

    Urvashi Rautela Serves Major Fitness Goals As She Enjoys A Quick Workout Session, Watch Video

    Urvashi Rautela Serves Major Fitness Goals As She Enjoys A Quick Workout Session, Watch Video

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    Fitness For Men: These are Five Exercises For A Sexy Back to Try

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    The Political Power of the Food Industry

    The Political Power of the Food Industry

    Top 3 Benefits of Infrared Sauna Blankets for Health and Recovery

    Top 3 Benefits of Infrared Sauna Blankets for Health and Recovery

    Are Nutrients Preserved by Pressure Cooking?  

    Are Nutrients Preserved by Pressure Cooking?  

    How A Low-FODMAP Diet Is Helping Me Feel Better

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    Treating Reflux in Kids with Diet 

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    When Is the Best Time to Floss? 

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    Sridevi collapsed because of a no-salt diet: What low sodium levels do to your body? | Health and Wellness News

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    Walking and Mediterranean diet may be the ticket to reducing dementia risk

    Walking and Mediterranean diet may be the ticket to reducing dementia risk

    Immunity Boosting Diet: 10 Superfoods Every Pregnant Woman MUST Eat Everyday

    Immunity Boosting Diet: 10 Superfoods Every Pregnant Woman MUST Eat Everyday

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    Valerie Bertinelli Calls Out Diet Culture While In Her ‘Fat Clothes’ From Jenny Craig Ad

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    ‘If L-G is concerned about citizens health, he should have acted against officers’

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    L-G gives nod to set up State Mental Health Authority- The New Indian Express

    L-G gives nod to set up State Mental Health Authority- The New Indian Express

    How to talk about mental health with your partner in a relationship

    How to talk about mental health with your partner in a relationship

    LG okays setting up State Mental Health Authority; slams Delhi govt for 5-year delay, ET HealthWorld

    LG okays setting up State Mental Health Authority; slams Delhi govt for 5-year delay, ET HealthWorld

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New Weight-Loss Drug Also Lowers Cholesterol Despite High Fat Diet: Study

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September 6, 2023
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New Weight-Loss Drug Also Lowers Cholesterol Despite High Fat Diet: Study

The treated mice completely lost their gained weight.

Medical researchers have been on a quest for safe weight-loss medications with minimal side effects for a while. It appears that they have now developed a promising solution to address this issue, which has reached epidemic proportions.

A biomedical engineer from the University of Massachusetts Amherst has harnessed a nanogel-based carrier, created in his laboratory, to selectively administer a drug to the livers of obese mice. This approach successfully reversed the disease induced by their dietary habits.

“The treated mice completely lost their weight, and we did not see any untoward side effects,” says S Thai Thayumanavan, distinguished professor of chemistry and biomedical engineering. “Considering 100 million Americans have obesity and related cardiometabolic disorders, we became pretty excited about this work.” 

Efforts to translate these findings to humans are being pursued by a start-up company called Cyta Therapeutics, which was founded at the UMass Institute for Applied Life Sciences (IALS) based on the nanogel technologies from the Thayumanavan lab. In late July, Cyta Therapeutics won the Judges’ Choice Award for Best Startup at the 16th annual Massachusetts Life Sciences Innovation (MALSI) Day in Boston.

“There is a significant amount of development work to be conducted between mice and humans,” Thayumanavan said in a news release, “but we are hoping it will eventually become a drug.” 

Senior author Thayumanavan, director of the Center for Bioactive Delivery at IALS, explains his team’s findings in a paper published Tuesday, August 29, in the Proceedings of the National Academy of Sciences NEXUS. Ruiling Wu, who is doing research for her PhD in chemistry in Thayumanavan’s lab and at the Center for Bioactive Delivery, is the paper’s lead author. Wu recently graduated and now works for a pharmaceutical company in Boston.

One of the center’s primary goals is to figure out how to get the right drug to the right place in the body by creating novel delivery platforms for small and large molecules.

Thyromimetics, or drugs that mimic synthetic thyroid hormone, have been considered a potential way to tackle the problems of obesity, type 2 diabetes, high cholesterol, metabolic dysfunction-associated steatohepatitis (MASH), and other metabolic conditions. Targeted therapy is key, however. Thayumanavan and his team looked at one such thyromimetic.

“We realized we needed to deliver this drug selectively to the liver because if it went to other places, it could cause complications,” he says. In addition to side effects, taking the drug systemically was expected to dilute its effectiveness, which was confirmed in the study. 

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