Women who struggle with getting enough sleep are at greater risk of developing high blood pressure, according to research published in Hypertension.
Researchers in the Channing Division of Network Medicine of Brigham and Women’s Hospital followed 66,122 participants between 25 and 42 years of age in the Nurses’ Health Study II cohort, all without hypertension at the study’s onset, over 16 years (from 2001 until 2017). Investigators collected information on participants’ age, race, body mass index (BMI), diet, lifestyle, physical activity, history of sleep apnea, and family history of hypertension and assessed the incidence of hypertension among the group every two years.
They first began measuring sleep duration in 2001, then did so again in 2009, recording the average number of hours slept over a 24-hour period. They also tracked sleeping difficulties, such as having trouble falling or staying asleep or waking up early in the morning, collecting responses at several time points throughout the study.
Data analyses revealed that women with sleeping difficulties had higher BMIs, lower physical activity, and poorer diets, on average. Researchers also found that those who struggled with sleep were more likely to smoke and drink alcohol and have previously gone through menopause.
Among the 25,987 cases of hypertension documented over the follow-up, women who slept less than seven to eight hours a night had a significantly higher risk of developing hypertension, according to the data collected. Similarly, women who had trouble falling asleep and staying asleep were also more likely to develop hypertension. Waking up early in the morning was not associated with this increased risk. Notably, these associations, remained significant after controlling for participant shift work schedules (night versus day shifts) and chronotype (morningness versus eveningness).
“These findings suggest that individuals who struggle with symptoms of insomnia may be at risk of hypertension and could benefit from preemptive screening,” says Shahab Haghayegh, PhD, a research fellow at the Brigham and Harvard Medical School, in a release. “Hypertension is associated with many other physical and mental health complications. The sooner we can identify individuals with high blood pressure and treat them for it, the better we can mitigate future health issues.”
While the exact nature of the relationship between sleep and risk of hypertension is unknown, Haghayegh notes that sleep difficulties can lead to a chain of events that can increase sodium retention, arterial stiffness, and cardiac output, potentially leading to hypertension. Disruptions to the sleep/wake cycle can also influence blood vessel constriction/relaxation activity and the function of cells that regulate the vascular tone.
While this study only looked at the association between sleep and hypertension in women, researchers hope to expand their work to include men and non-binary participants. A second limitation is that researchers could only collect data on sleep quality at select time points throughout the study. Some of the study’s strengths include the larger number of participants and length of follow-up duration.
Haghayegh emphasizes that these findings do not indicate causality. He wants to understand why this association exists and how treating one condition may also treat the other. In future clinical studies, he aims to investigate if sleep medications could have a beneficial effect on blood pressure.
“I hope these findings further underscore the crucial role of quality sleep in our overall well-being. The American Academy of Sleep Medicine recommends sleeping seven or more hours a night, and if you cannot fall or stay asleep, it might be worth exploring why that is,” says Haghayegh in the release. “This study highlights yet another reason why getting a good night’s sleep is so important.”
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