✔ Evidence-Based. Medically Assessed by Michael Sharpe, MSc as well as Dr. Michael Tamber, MD.
Dimethylnandrolone Undecanoate (DMAU), Trestolone (MENT), as well as 11-methyl-19-nortestosterone (11-MNT) are sister chemicals being examined as a male birth control pill and also as testosterone substitute.
Dimethandrolone (DMA), additionally recognized by its appointed code word CDB-1321 or as DMAU in its undecanoate esterified type, is an investigational progestogen as well as androgenic anabolic steroid (AAS) that is being looked into for feasible healing application.
In contrast to trestolone, DMAU is a premium selection for hormonal agent substitute, according to scientists. Trestolone has a really brief fifty percent life. (1, 2, 3)
Additionally, DMAU restricts sperm manufacturing however does not reduced sex drive or hinder climaxing, according to arise from previous researches. (2, 3)
- DMAU remains in growth as a male birth control.
- 2019 Stage I human medical researches achieved success as well as it was considered safe as well as well-tolerated.
- After cessation, spermatogenesis returns swiftly.
- Can be orally-administered or provided as shot.
- Does not have aromatase activity.
- DMAU is 136 times much more myotrophic than testosterone. It is anabolic than its sibling chemicals trestolone (MENT) as well as 11β-methyl-19-nortestosterone (11β-MNT).
DMAU as a Man Birth Control
At the optimum examined dosage of DMAU, 400 mg, people had significant decrease of degrees of the sperm-producing hormonal agents LH, FSH, as well as testosterone (4 )
Regardless of having reduced flowing testosterone degrees, just a handful of individuals revealed signs and symptoms related to either excess or deficiency of testosterone.
Researches
Eighty-two individuals participated in the test. There were no substantial adverse results. Security lab dimensions did not modify in a scientifically appropriate method. (5 )
Daily dental management of DMAU for 28 days in healthy and balanced males is well endured. Dosages of ≥ 200 mg substantially reduced product testosterone, LH, as well as FSH. (5 )
Androgen Substitute
According to every one of the information accumulated, androgen substitute with DMAU or 11-MNTDC in Cx rats caused valuable changes in body structure as well as the upkeep of done mineral thickness that amounted that of testosterone. (6 )
Does Not 5α-Reductase
DMAU is not vulnerable to metabolic rate by the 5-reductase enzyme. (7 )
The feature of 5-reduction in the androgenic task of DMA as well as MNT was checked out considering that 5-reduced androgens, such as DHT, might raise the danger of benign prostate hyperplasia, speed up the growth of prostate cancer cells, as well as raise male pattern baldness as well as acne. (7 )
According to the searchings for, preventing the task of 5-reductase in vivo has no result on the androgenic effectiveness of DMA, MNT, or MENT. (7 )
Does Not Seem to Aromatase
The possibility of customers experiencing oestrogenic negative results is absolutely no, case specialists at the US-based Bioqual. Dimethandrolone did not exchange oestrogenic compounds throughout examinations in examination tubes. (8 )
Recommendations
This area consists of web links to research study, researches, as well as resources of details for this write-up, along with writers, factors, and so on. All resources, together with the write-up as well as realities, undergo a collection of high quality, integrity, as well as significance checks.
Actual Muscular tissue mainly utilizes top notch resources, such as peer-reviewed magazines, to support the details in our short articles. To recognize even more concerning just how we fact-check as well as maintain our details exact, reputable, as well as trustworthy, learn more concerning us
This evidence-based evaluation of Dimethylnandrolone Undecanoate (DMAU) includes 8 referrals, listed here.
1. Attardi BJ, Hild SA, Reel JR. Dimethandrolone undecanoate: a brand-new powerful by mouth energetic androgen with progestational task Endocrinology. (2006 )
2. Walton, Melanie J., et al. 7α-methyl-19-nortestosterone (MENT) vs Testosterone in Mix With Etonogestrel Implants for Spermatogenic Reductions in Healthy And Balanced Male Journal of Andrology. (2007 )
3. Kumar N, Suvisaari J, Tsong YY, et al. Pharmacokinetics of 7 alpha-methyl-19-nortestosterone in males as well as cynomolgus apes J Androl. (1997 )
4. Dimethandrolone Undecanoate Reveals Assurance as a Male Contraceptive Pill
5. Thirumalai A, Ceponis J, Amory JK, et al. Impacts of 28 Days of Oral Dimethandrolone Undecanoate in Healthy And Balanced Male: A Model Male Tablet J Clin Endocrinol Metab. (2019) (Scientific Test)
6. Attardi BJ, Marck BT, Matsumoto AM, Koduri S, Hild SA. Long-lasting results of dimethandrolone 17β-undecanoate as well as 11β-methyl-19-nortestosterone 17β-dodecylcarbonate on body structure, bone mineral thickness, product gonadotropins, as well as androgenic/anabolic task in castrated male rats J Androl. (2011 )
7. Attardi BJ, Hild SA, Koduri S, et al. The powerful artificial androgens, dimethandrolone (7α,11 β-dimethyl-19-nortestosterone) as well as 11β-methyl-19-nortestosterone, do not call for 5α-reduction to apply their ultimate androgenic results J Steroid Biochem Mol Biol. (2010 )
8. Beast anabolic dimethandrolone does not aromatize
The details supplied in this write-up is not planned to change expert clinical guidance, medical diagnosis, or therapy. Constantly look for the advice of a medical professional or various other skilled expert prior to adhering to guidance or taking any type of supplement. See our conditions
We purely do not recommend anybody to utilize, or take into consideration making use of, any type of exogenous hormonal agent or chemical such as trestolone, unless recommended or recommended to do so by a certified physician. Doing so can cause severe as well as long-lasting negative results.
